new_vine_copula_ss_fit

In a clinical trial, it frequently occurs that the most credible
outcome to evaluate the effectiveness of a new therapy (the true endpoint) is
difficult to measure. In such a situation, it can be an effective strategy to
replace the true endpoint by a (bio)marker that is easier to measure and that
allows for a prediction of the treatment effect on the true endpoint (a
surrogate endpoint). The package 'Surrogate' allows for an evaluation of the
appropriateness of a candidate surrogate endpoint based on the meta-analytic,
information-theoretic, and causal-inference frameworks. Part of this software
has been developed using funding provided from the European Union's Seventh
Framework Programme for research, technological development and demonstration
(Grant Agreement no 602552), the Special Research Fund (BOF) of Hasselt
University (BOF-number: BOF2OCPO3), GlaxoSmithKline Biologicals, Baekeland
Mandaat (HBC.2022.0145), and Johnson & Johnson Innovative Medicine.

Wim der Elst

Surrogate

Evaluation of Surrogate Endpoints in Clinical Trials

Wim Van Der Elst

Florian Stijven

Fenny Ong

Dries De Witte

Paul Meyvisch

Alvaro Poveda

Ariel Alonso

Hannah Ensor

Christoper Weir

Geert Molenberghs

new_vine_copula_ss_fit function

<dl><dt>fit_0</dt>
<dd>Estimated parameters in the control group.</dd>
<dt>fit_1</dt>
<dd>Estimated parameters in the experimental group</dd>
<dt>copula_family</dt>
<dd>Parametric copula family</dd>
<dt>knots0</dt>
<dd>placement of knots for Royston-Parmar model</dd>
<dt>knots1</dt>
<dd>placement of knots for Royston-Parmar model</dd>
<dt>knott0</dt>
<dd>placement of knots for Royston-Parmar model</dd>
<dt>knott1</dt>
<dd>placement of knots for Royston-Parmar model</dd>
<dt>copula_rotations</dt>
<dd>vector of copula rotation parameters</dd>
<dt>data</dt>
<dd>Original data</dd></dl>

Arguments

Constructor for vine copula model — new_vine_copula_ss_fit

<dl>

<dt>fit_0</dt>
<dd>Estimated parameters in the control group.</dd>


<dt>fit_1</dt>
<dd>Estimated parameters in the experimental group</dd>


<dt>copula_family</dt>
<dd>Parametric copula family</dd>


<dt>knots0</dt>
<dd>placement of knots for Royston-Parmar model</dd>


<dt>knots1</dt>
<dd>placement of knots for Royston-Parmar model</dd>


<dt>knott0</dt>
<dd>placement of knots for Royston-Parmar model</dd>


<dt>knott1</dt>
<dd>placement of knots for Royston-Parmar model</dd>


<dt>copula_rotations</dt>
<dd>vector of copula rotation parameters</dd>


<dt>data</dt>
<dd>Original data</dd>

</dl>

Constructor for vine copula model

new_vine_copula_ss_fit: Constructor for vine copula model

Description

Usage

Value

Arguments

Examples