TERAplusB (version 1.0)

TER.deesc.A.B: Find the bootstrap distribution

Description

TER.deesc.A.B finds all possible combinations of A+B design with specific dose-toxicity relations.

Usage

TER.deesc.A.B(Dose,Prob.Dose,A,B,C,D,E)

Arguments

Dose

Dose levels

Prob.Dose

True Probability of toxicity

A

Number of patients in each level

B

Number of added patients

C

Cutoff point 1

D

Cutoff point 2

E

Cutoff point 3

Value

tot.list

All possible combinations of 1+B design

Prob.result

Exact distribution of MTD

E.toxrate

Expected toxicity rate

E.n

Expected number of patients

E.time

Expected number of periods

References

Adaptive Design Methods in Clinical Trials - Chow and Chung

Examples

     library(TERAplusB)
     TER.deesc.A.B(c("D1","D2"),c(0.2,0.7),A=3,B=3,C=1,D=2,E=2)