UCSCXenaShiny (version 2.1.0)

analyze_gene_drug_response_asso: Analyze Association between Gene (Signature) and Drug Response with CCLE Data

Description

Analyze partial correlation of gene-drug association after controlling for tissue average expression.

Usage

analyze_gene_drug_response_asso(gene_list, combine = FALSE)

Value

a data.frame

• If combine is TRUE, genes are combined as signature.

• mean.diff and median.diff indicate mean and median of normalized expression difference between High IC50 cells and Low IC50 cells. The cutoff between High and Low are median IC50.

Arguments

gene_list

a gene symbol list.

combine

if TRUE, combine the expression of gene list as a gene signature.

Examples

if (FALSE) {
analyze_gene_drug_response_asso("TP53")
analyze_gene_drug_response_asso(c("TP53", "KRAS"))
analyze_gene_drug_response_asso(c("TP53", "KRAS"), combine = TRUE)

# Visualization
vis_gene_drug_response_asso("TP53")
}