# This example mimics the example in Efron (1986).
# The results here differ slightly.
# Scale the variables
toxop <- transform(toxop,
                   phat = positive / ssize,
                   srainfall = scale(rainfall),  # (6.1)
                   sN = scale(ssize))            # (6.2)
# A fit similar (should be identical) to Sec.6 of Efron (1986).
# But does not use poly(), and M = 1.25 here, as in (5.3)
cmlist <- list("(Intercept)"    = diag(2),
               "I(srainfall)"   = rbind(1, 0),
               "I(srainfall^2)" = rbind(1, 0),
               "I(srainfall^3)" = rbind(1, 0),
               "I(sN)" = rbind(0, 1),
               "I(sN^2)" = rbind(0, 1))
fit <-
  vglm(cbind(phat, 1 - phat) * ssize ~
       I(srainfall) + I(srainfall^2) + I(srainfall^3) +
       I(sN) + I(sN^2),
       double.expbinomial(ldisp = "extlogitlink(min = 0, max = 1.25)",
                          idisp = 0.2, zero = NULL),
       toxop, trace = TRUE, constraints = cmlist)
# Now look at the results
coef(fit, matrix = TRUE)
head(fitted(fit))
summary(fit)
vcov(fit)
sqrt(diag(vcov(fit)))  # Standard errors
# Effective sample size (not quite the last column of Table 1)
head(predict(fit))
Dispersion <- extlogitlink(predict(fit)[,2], min = 0, max = 1.25,
                           inverse = TRUE)
c(round(weights(fit, type = "prior") * Dispersion, digits = 1))
# Ordinary logistic regression (gives same results as (6.5))
ofit <- vglm(cbind(phat, 1 - phat) * ssize ~
             I(srainfall) + I(srainfall^2) + I(srainfall^3),
             binomialff, toxop, trace = TRUE)
# Same as fit but it uses poly(), and can be plotted (cf. Fig.1)
cmlist2 <- list("(Intercept)"                 = diag(2),
                "poly(srainfall, degree = 3)" = rbind(1, 0),
                "poly(sN, degree = 2)"        = rbind(0, 1))
fit2 <-
  vglm(cbind(phat, 1 - phat) * ssize ~
       poly(srainfall, degree = 3) + poly(sN, degree = 2),
       double.expbinomial(ldisp = "extlogitlink(min = 0, max = 1.25)",
                          idisp = 0.2, zero = NULL),
       toxop, trace = TRUE, constraints = cmlist2)
if (FALSE)  par(mfrow = c(1, 2))  # Cf. Fig.1
plot(as(fit2, "vgam"), se = TRUE, lcol = "blue", scol = "orange")
# Cf. Figure 1(a)
par(mfrow = c(1,2))
ooo <- with(toxop, sort.list(rainfall))
with(toxop, plot(rainfall[ooo], fitted(fit2)[ooo], type = "l",
                 col = "blue", las = 1, ylim = c(0.3, 0.65)))
with(toxop, points(rainfall[ooo], fitted(ofit)[ooo],
                   col = "orange", type = "b", pch = 19))
# Cf. Figure 1(b)
ooo <- with(toxop, sort.list(ssize))
with(toxop, plot(ssize[ooo], Dispersion[ooo], type = "l",
                 col = "blue", las = 1, xlim = c(0, 100))) 
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