XGR (version 1.1.7)

Haploid_regulators: Haploid mutagenesis screens for regulators of protein phenotypes

Description

This dataset contains regulators of 11 protein phenotypes identified by haploid mutagenesis screens.

Usage

data(Haploid_regulators)

Value

a data frame. It has the following columns: "Gene" (gene symbol; regulators), "MI" (mutation index; negative values for positive regulators and positive values for negative regulators), "FDR" and "Phenotype" (one of 11 protein phenotypes).

References

Brockmann et al. (2017). Genetic wiring maps of single-cell protein states reveal an off-switch for GPCR signalling. Nature, 546:307-11.

Mezzadra et al. (2017). Identification of CMTM6 and CMTM4 as PD-L1 protein regulators. Nature, 549:106-10.

Examples

# NOT RUN {
Haploid_regulators <- xRDataLoader('Haploid_regulators')
Haploid_regulators[1:5,]
## for 'PDL1'
ind <- grepl('PDL1', Haploid_regulators$Phenotype)
df <- Haploid_regulators[ind,c('Gene','MI','FDR')]
# }