SurvivalDesign

SurvivalDesign,TwoStageDesign-method

TwoStageDesign,TwoStageDesign-method

OneStageDesign,OneStageDesign-method

SurvivalDesign,OneStageDesign-method

GroupSequentialDesign,GroupSequentialDesign-method

SurvivalDesign,GroupSequentialDesign-method

<code>SurvivalDesign</code> is a function that converts an arbitrary design to a survival design.

Optimize one or two-arm, two-stage designs for clinical trials with
respect to several implemented objective criteria or custom objectives.
Optimization under uncertainty and conditional (given stage-one outcome)
constraints are supported.
See Pilz et al. (2019) <doi:10.1002/sim.8291> and
Kunzmann et al. (2021) <doi:10.18637/jss.v098.i09> for details.

Maximilian Pilz

adoptr

Adaptive Optimal Two-Stage Designs

Kevin Kunzmann

Jan Meis

Nico Bruder

SurvivalDesign function

<dl><dt>design</dt>
<dd>design that should be converted to a survival design</dd>
<dt>event_rate</dt>
<dd>probability that a subject in either group will eventually have an event</dd>
<dt>n1</dt>
<dd>design object to convert (overloaded from <code>TwoStageDesign</code>)</dd>
<dt>n</dt>
<dd>design object to convert (overloaded from <code>TwoStageDesign</code>)</dd></dl>

Arguments

SurvivalDesign — SurvivalDesign

<dl>

<dt>design</dt>
<dd>design that should be converted to a survival design</dd>


<dt>event_rate</dt>
<dd>probability that a subject in either group will eventually have an event</dd>


<dt>n1</dt>
<dd>design object to convert (overloaded from <code>TwoStageDesign</code>)</dd>


<dt>n</dt>
<dd>design object to convert (overloaded from <code>TwoStageDesign</code>)</dd>

</dl>

SurvivalDesign: SurvivalDesign

Description

Usage

Value

Arguments

Examples