Sigma

A generic, easy-to-use and expandable implementation of a
pharmacokinetic (PK) / pharmacodynamic (PD) model based on the S4
class system. This package allows the user to read/write a
pharmacometric model from/to files and adapt it further on the fly in
the R environment. For this purpose, this package provides an
intuitive API to add, modify or delete equations, ordinary
differential equations (ODE's), model parameters or compartment
properties (like infusion duration or rate, bioavailability and
initial values). Finally, this package also provides a useful export
of the model for use with simulation packages 'rxode2' and 'mrgsolve'.
This package is designed and intended to be used with package
'campsis', a PK/PD simulation platform built on top of 'rxode2' and
'mrgsolve'.

Nicolas Luyckx

campsismod

Generic Implementation of a PK/PD Model

Sigma function

<dl><dt>name</dt>
<dd>parameter name, e.g. CL (prefix SIGMA will be added automatically)</dd>
<dt>index</dt>
<dd>parameter index</dd>
<dt>index2</dt>
<dd>second parameter index</dd>
<dt>value</dt>
<dd>parameter value</dd>
<dt>min</dt>
<dd>minimum value for this parameter when parameter uncertainty is enabled</dd>
<dt>max</dt>
<dd>maximum value for this parameter when parameter uncertainty is enabled</dd>
<dt>fix</dt>
<dd>parameter was fixed in estimation, logical value</dd>
<dt>type</dt>
<dd>variance type: 'var', 'sd', 'covar', 'cv' or 'cv%'</dd>
<dt>label</dt>
<dd>parameter label, optional</dd>
<dt>comment</dt>
<dd>any comment, optional</dd></dl>

Arguments

Create a SIGMA parameter. — Sigma

<dl>

<dt>name</dt>
<dd>parameter name, e.g. CL (prefix SIGMA will be added automatically)</dd>


<dt>index</dt>
<dd>parameter index</dd>


<dt>index2</dt>
<dd>second parameter index</dd>


<dt>value</dt>
<dd>parameter value</dd>


<dt>min</dt>
<dd>minimum value for this parameter when parameter uncertainty is enabled</dd>


<dt>max</dt>
<dd>maximum value for this parameter when parameter uncertainty is enabled</dd>


<dt>fix</dt>
<dd>parameter was fixed in estimation, logical value</dd>


<dt>type</dt>
<dd>variance type: 'var', 'sd', 'covar', 'cv' or 'cv%'</dd>


<dt>label</dt>
<dd>parameter label, optional</dd>


<dt>comment</dt>
<dd>any comment, optional</dd>

</dl>

Sigma: Create a SIGMA parameter.

Description

Usage

Value

Arguments