auto_replication_settings-class

A generic, easy-to-use and expandable implementation of a
pharmacokinetic (PK) / pharmacodynamic (PD) model based on the S4
class system. This package allows the user to read/write a
pharmacometric model from/to files and adapt it further on the fly in
the R environment. For this purpose, this package provides an
intuitive API to add, modify or delete equations, ordinary
differential equations (ODE's), model parameters or compartment
properties (like infusion duration or rate, bioavailability and
initial values). Finally, this package also provides a useful export
of the model for use with simulation packages 'rxode2' and 'mrgsolve'.
This package is designed and intended to be used with package
'campsis', a PK/PD simulation platform built on top of 'rxode2' and
'mrgsolve'.

Nicolas Luyckx

campsismod

Generic Implementation of a PK/PD Model

auto_replication_settings-class function

<dl>
<dt><code>wishart</code></dt>
<dd>logical, sample OMEGAs and SIGMAs from scaled inverse chi-squared or Wishart distributions</dd></dl>
<dt><code>odf</code></dt>
<dd>the degrees of freedom for the scaled inverse chi-squared/Wishart distribution with regards to the OMEGAs, integer vector</dd>
<dt><code>sdf</code></dt>
<dd>the degrees of freedom for the scaled inverse chi-squared/Wishart distribution with regards to the SIGMAs, integer vector</dd>
<dt><code>quiet</code></dt>
<dd>logical, suppress info messages</dd>
<dt><code>max_iterations</code></dt>
<dd>number of iterations maximum to sample the parameters</dd>
<dt><code>max_chunk_size</code></dt>
<dd>maximum number of rows to sample at once, default value will be the number of replicates, unless specified.</dd>
<dt><code>check_min_max</code></dt>
<dd>logical, check for min/max values when sampling the parameters</dd>
<dt><code>check_pos_def</code></dt>
<dd>logical, check for positive definiteness when sampling the OMEGA/SIGMA parameters</dd>
<dt><code>wishart_correction</code></dt>
<dd>logical, FALSE is default, see https://github.com/metrumresearchgroup/simpar/issues/11</dd>

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Auto replication settings class. — auto_replication_settings-class

<dl>
<dt><code>wishart</code></dt>
<dd>logical, sample OMEGAs and SIGMAs from scaled inverse chi-squared or Wishart distributions</dd>


<dt><code>odf</code></dt>
<dd>the degrees of freedom for the scaled inverse chi-squared/Wishart distribution with regards to the OMEGAs, integer vector</dd>


<dt><code>sdf</code></dt>
<dd>the degrees of freedom for the scaled inverse chi-squared/Wishart distribution with regards to the SIGMAs, integer vector</dd>


<dt><code>quiet</code></dt>
<dd>logical, suppress info messages</dd>


<dt><code>max_iterations</code></dt>
<dd>number of iterations maximum to sample the parameters</dd>


<dt><code>max_chunk_size</code></dt>
<dd>maximum number of rows to sample at once, default value will be the number of replicates, unless specified.</dd>


<dt><code>check_min_max</code></dt>
<dd>logical, check for min/max values when sampling the parameters</dd>


<dt><code>check_pos_def</code></dt>
<dd>logical, check for positive definiteness when sampling the OMEGA/SIGMA parameters</dd>


<dt><code>wishart_correction</code></dt>
<dd>logical, FALSE is default, see https://github.com/metrumresearchgroup/simpar/issues/11</dd>


</dl>

auto_replication_settings-class: Auto replication settings class.

Description

Arguments

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