regression modeling of subdistribution functions in competing risks
crr(ftime, fstatus, cov1, cov2, tf, cengroup, failcode=1, cencode=0,
subset, na.action=na.omit, gtol=1e-06, maxiter=10, init, variance=TRUE)Returns a list of class crr, with components
the estimated regression coefficients
log pseudo-liklihood evaluated at coef
derivitives of the log pseudo-likelihood evaluated at coef
-second derivatives of the log pseudo-likelihood
estimated variance covariance matrix of coef
matrix of residuals giving the contribution to each score (columns) at each unique failure time (rows)
vector of unique failure times
jumps in the Breslow-type estimate of the underlying sub-distribution cumulative hazard (used by predict.crr())
the tfs matrix (output of tf(), if used)
TRUE if the iterative algorithm converged
The call to crr
The number of observations used in fitting the model
The number of observations removed from the input data due to missing values
The value of the log pseudo-likelihood when all the coefficients are 0
- inverse of second derivative matrix of the log pseudo-likelihood
vector of failure/censoring times
vector with a unique code for each failure type and a separate code for censored observations
matrix (nobs x ncovs) of fixed covariates (either cov1, cov2, or both are required)
matrix of covariates that will be multiplied by functions of time; if used, often these covariates would also appear in cov1 to give a prop hazards effect plus a time interaction
functions of time. A function that takes a vector of times as
an argument and returns a matrix whose jth column is the value of
the time function corresponding to the jth column of cov2 evaluated
at the input time vector. At time tk, the
model includes the term cov2[,j]*tf(tk)[,j] as a covariate.
vector with different values for each group with a distinct censoring distribution (the censoring distribution is estimated separately within these groups). All data in one group, if missing.
code of fstatus that denotes the failure type of interest
code of fstatus that denotes censored observations
a logical vector specifying a subset of cases to include in the analysis
a function specifying the action to take for any cases missing any of ftime, fstatus, cov1, cov2, cengroup, or subset.
iteration stops when a function of the gradient is < gtol
maximum number of iterations in Newton algorithm (0 computes
scores and var at init, but performs no iterations)
initial values of regression parameters (default=all 0)
If FALSE, then suppresses computation of the variance estimate
and residuals
Fits the 'proportional subdistribution hazards' regression model described in Fine and Gray (1999). This model directly assesses the effect of covariates on the subdistribution of a particular type of failure in a competing risks setting. The method implemented here is described in the paper as the weighted estimating equation.
While the use of model formulas is not supported, the
model.matrix function can be used to generate suitable matrices
of covariates from factors, eg
model.matrix(~factor1+factor2)[,-1] will generate the variables
for the factor coding of the factors factor1 and factor2.
The final [,-1] removes the constant term from the output of
model.matrix.
The basic model assumes the subdistribution with covariates z is a
constant shift on the complementary log log scale from a baseline
subdistribution function. This can be generalized by including
interactions of z with functions of time to allow the magnitude of the
shift to change with follow-up time, through the cov2 and tfs
arguments. For example, if z is a vector of covariate values, and uft
is a vector containing the unique failure times for failures of the
type of interest (sorted in ascending order), then the coefficients a,
b and c in the quadratic (in time) model
\(az+bzt+zt^2\) can be fit
by specifying cov1=z, cov2=cbind(z,z),
tf=function(uft) cbind(uft,uft*uft).
This function uses an estimate of the survivor function of the censoring distribution to reweight contributions to the risk sets for failures from competing causes. In a generalization of the methodology in the paper, the censoring distribution can be estimated separately within strata defined by the cengroup argument. If the censoring distribution is different within groups defined by covariates in the model, then validity of the method requires using separate estimates of the censoring distribution within those groups.
The residuals returned are analogous to the Schoenfeld residuals in ordinary survival models. Plotting the jth column of res against the vector of unique failure times checks for lack of fit over time in the corresponding covariate (column of cov1).
If variance=FALSE, then
some of the functionality in summary.crr and print.crr
will be lost. This option can be useful in situations where crr is
called repeatedly for point estimates, but standard errors are not
required, such as in some approaches to stepwise model selection.
Fine JP and Gray RJ (1999) A proportional hazards model for the subdistribution of a competing risk. JASA 94:496-509.
predict.crr print.crr plot.predict.crr
summary.crr
# simulated data to test
set.seed(10)
ftime <- rexp(200)
fstatus <- sample(0:2,200,replace=TRUE)
cov <- matrix(runif(600),nrow=200)
dimnames(cov)[[2]] <- c('x1','x2','x3')
print(z <- crr(ftime,fstatus,cov))
summary(z)
z.p <- predict(z,rbind(c(.1,.5,.8),c(.1,.5,.2)))
plot(z.p,lty=1,color=2:3)
crr(ftime,fstatus,cov,failcode=2)
# quadratic in time for first cov
crr(ftime,fstatus,cov,cbind(cov[,1],cov[,1]),function(Uft) cbind(Uft,Uft^2))
#additional examples in test.R
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