Levels of expressed alpha synuclein mRNA in three groups of allele lengths
of NACP-REP1.
Usage
data("alpha")
Arguments
source
Dominikus B"onsch, Thomas Lederer, Udo Reulbach, Torsten Hothorn,
Johannes Kornhuber & Stefan Bleich (2005).
Joint Analysis of the NACP-REP1 Marker Within the Alpha
Synuclein Gene Concludes Association with Alcohol Dependence.
Human Molecular Genetics, 14(7), 967--971.
Torsten Hothorn, Kurt Hornik, Mark A. van de Wiel & Achim Zeileis (2006).
A Lego system for conditional inference, The American Statistician,
60(3), 257--263.
Details
Various studies have linked alcohol dependence phenotypes to chromosome 4.
One candidate gene is NACP (non-amyloid component of plaques),
coding for alpha synuclein. B"onsch et al. (2005) found longer alleles of
NACP-REP1 in alcohol-dependent patients compared with healthy
controls and report that the allele lengths show some
association with levels of expressed alpha synuclein mRNA.