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coin (version 1.0-24)

alpha: Genetic Components of Alcoholism

Description

Levels of expressed alpha synuclein mRNA in three groups of allele lengths of NACP-REP1.

Usage

data("alpha")

Arguments

source

Dominikus B"onsch, Thomas Lederer, Udo Reulbach, Torsten Hothorn, Johannes Kornhuber & Stefan Bleich (2005). Joint Analysis of the NACP-REP1 Marker Within the Alpha Synuclein Gene Concludes Association with Alcohol Dependence. Human Molecular Genetics, 14(7), 967--971.

Torsten Hothorn, Kurt Hornik, Mark A. van de Wiel & Achim Zeileis (2006). A Lego system for conditional inference, The American Statistician, 60(3), 257--263.

Details

Various studies have linked alcohol dependence phenotypes to chromosome 4. One candidate gene is NACP (non-amyloid component of plaques), coding for alpha synuclein. B"onsch et al. (2005) found longer alleles of NACP-REP1 in alcohol-dependent patients compared with healthy controls and report that the allele lengths show some association with levels of expressed alpha synuclein mRNA.

Examples

Run this code
boxplot(elevel ~ alength, data = alpha)
  kruskal_test(elevel ~ alength, data = alpha)

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