coin (version 1.0-24)

asat: Toxicological Study on Female Wistar Rats

Description

ASAT-values for a new compound and a control group of 34 female Wistar rats.

Usage

data("asat")

source

Ludwig A. Hothorn (1992), Biometrische Analyse toxikologischer Untersuchungen. In: J. Adams (ed.): Statistisches Know how in der medizinischen Forschung. Ullstein-Mosby, Berlin, 475--590.

Details

The aim of this toxicological study is the proof of safety for the new compound. The data are originally given in Hothorn (1992) and reproduced in Hauschke et al. (1999).

References

Dieter Hauschke, Meinhard Kieser & Ludwig A. Hothorn (1999). Proof of safety in toxicology based on the ratio of two means for normally distributed data, Biometrical Journal 41(3), 295--304.

Rafael Pfl"uger & Torsten Hothorn (2002). Assessing equivalence tests with respect to their expected $p$-Value, Biometrical Journal 44(8), 1002--1027.

Examples

### proof-of-safety based on ratio of medians
  pos <- wilcox_test(I(log(asat)) ~ group, data = asat, alternative = "less", 
                     conf.int = TRUE, distribution = "exact")

  ### one-sided confidence set. Safety cannot be concluded since the effect of
  ### the compound exceeds 20\% of the control median
  exp(confint(pos)$conf.int)