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coxme (version 2.2-22)

coxmeMlist: Coxme variance function

Description

This variance function accepts a list of matrices, which define a correlation structure for a coxme fit.

Usage

coxmeMlist(varlist, rescale = FALSE, pdcheck = TRUE, positive = TRUE)

Value

a coxme variance family object, used by coxme in the fitting process.

Arguments

varlist

a list containing one or more matrix or bdsmatrix objects.

rescale

if TRUE, each input matrix is rescaled to have a diagonal of 1. (Kinship matrices for instance are often generated with a diagonal of .5 and would be multiplied by 2).

pdcheck

check each matrix to ensure that it is positive definite

positive

constrain coefficients to be positive. This may also be a vector of the same length as varlist

Author

Terry Therneau

Details

If two matrices \(A\) and \(B\) were given, this fits the variance structure \(V= \sigma_1^2 A + \sigma_2^2 B\), where the variances \(\sigma_1^2\) and \(\sigma_2^2\) are parameters that will be optimized by coxme, treating \(A\) and \(B\) as fixed.

See Also

coxme