crmPack (version 1.0.6)

CohortSizeMax-class: Size based on maximum of multiple cohort size rules

Description

This class can be used to combine multiple cohort size rules with the MAX operation.

Slots

cohortSizeList

list of cohort size rules

Details

cohortSizeList contains all cohort size rules, which are again objects of class CohortSize. The maximum of these individual cohort sizes is taken to give the final cohort size.

Examples

# Rule for having cohort of size 1 for doses <30
#      and having cohort of size 3 for doses >=30
mySize1 <- CohortSizeRange(intervals = c(0, 10),
                           cohortSize = c(1, 3))

# Rule for having cohort of size 1 until no DLT were observed
#      and having cohort of size 3 as soon as 1 DLT is observed
mySize2 <- CohortSizeDLT(DLTintervals=c(0, 1),
                         cohortSize=c(1, 3))

# Create a list of cohort size rules of class 'CohortSizeMax' which will then be 
# combined with the 'max' operation
mySize <- CohortSizeMax(cohortSizeList=list(mySize1, 
                                            mySize2))