crmPack (version 1.0.6)

DataMixture-class: Class for the data with mixture sharing

Description

Class for the data with mixture sharing

Slots

xshare

the doses for the share patients

yshare

the vector of toxicity events (0 or 1 integers) for the share patients

nObsshare

number of share patients

See Also

LogisticLogNormalMixture for the explanation how to use this data class

Examples

## decide on the dose grid:
doseGrid <- 1:80

## and MCMC options:
options <- McmcOptions()

## the classic model would be:
model <- LogisticLogNormal(mean = c(-0.85, 1),
                           cov = matrix(c(1, -0.5, -0.5, 1), nrow = 2),
                           refDose = 50)

nodata <- Data(doseGrid=doseGrid)

priorSamples <- mcmc(nodata, model, options)
plot(priorSamples, model, nodata)

## set up the mixture model and data share object:
modelShare <- LogisticLogNormalMixture(shareWeight=0.1,
                                       mean = c(-0.85, 1),
                                       cov = matrix(c(1, -0.5, -0.5, 1), nrow = 2),
                                       refDose = 50)

nodataShare <- DataMixture(doseGrid=doseGrid,
                           xshare=
                             c(rep(10, 4),
                               rep(20, 4),
                               rep(40, 4)),
                           yshare=
                             c(rep(0L, 4),
                               rep(0L, 4),
                               rep(0L, 4)))

## now compare with the resulting prior model:
priorSamplesShare <- mcmc(nodataShare, modelShare, options)
plot(priorSamplesShare, modelShare, nodataShare)