Design

Initialization function for "Design"

methods

Implements a wide range of model-based dose
escalation designs, ranging from classical and modern continual
reassessment methods (CRMs) based on dose-limiting toxicity endpoints to
dual-endpoint designs taking into account a biomarker/efficacy outcome. The
focus is on Bayesian inference, making it very easy to setup a new design
with its own JAGS code. However, it is also possible to implement 3+3
designs for comparison or models with non-Bayesian estimation. The whole
package is written in a modular form in the S4 class system, making it very
flexible for adaptation to new models, escalation or stopping rules.

Daniel Sabanes Bove

crmPack

Object-Oriented Implementation of CRM Designs

Wai Yin Yeung

Giuseppe Palermo

Thomas Jaki

Design function

<dl><dt>model</dt>
<dd>see <code>Design</code></dd>
<dt>stopping</dt>
<dd>see <code>Design</code></dd>
<dt>increments</dt>
<dd>see <code>Design</code></dd>
<dt>PLcohortSize</dt>
<dd>see <code>Design</code></dd>
<dt>...</dt>
<dd>additional arguments for <code>RuleDesign</code></dd></dl>

Arguments

Initialization function for "Design" — Design

<dl>

<dt>model</dt>
<dd>see <code>Design</code></dd>


<dt>stopping</dt>
<dd>see <code>Design</code></dd>


<dt>increments</dt>
<dd>see <code>Design</code></dd>


<dt>PLcohortSize</dt>
<dd>see <code>Design</code></dd>


<dt>...</dt>
<dd>additional arguments for <code>RuleDesign</code></dd>

</dl>

Design: Initialization function for "Design"

Description

Usage

Value

Arguments