Effloglog

Initialization function for the "Effloglog" class

methods

Implements a wide range of model-based dose
escalation designs, ranging from classical and modern continual
reassessment methods (CRMs) based on dose-limiting toxicity endpoints to
dual-endpoint designs taking into account a biomarker/efficacy outcome. The
focus is on Bayesian inference, making it very easy to setup a new design
with its own JAGS code. However, it is also possible to implement 3+3
designs for comparison or models with non-Bayesian estimation. The whole
package is written in a modular form in the S4 class system, making it very
flexible for adaptation to new models, escalation or stopping rules.

Daniel Sabanes Bove

crmPack

Object-Oriented Implementation of CRM Designs

Wai Yin Yeung

Giuseppe Palermo

Thomas Jaki

Effloglog function

<dl><dt>Eff</dt>
<dd>the pseudo efficacy responses</dd>
<dt>Effdose</dt>
<dd>the corresponding dose levels for the pseudo efficacy responses</dd>
<dt>nu</dt>
<dd>the precision (inverse of the variance) of the efficacy responses</dd>
<dt>data</dt>
<dd>the input data of <code>DataDual</code> class to update model estimates</dd>
<dt>c</dt>
<dd>the constant value added to the dose level when the dose level value is less than or
equal to 1 and a special form of the linear log-log has to applied (Yeung et al. (2015).).</dd></dl>

Arguments

Initialization function for the "Effloglog" class — Effloglog

<dl>

<dt>Eff</dt>
<dd>the pseudo efficacy responses</dd>


<dt>Effdose</dt>
<dd>the corresponding dose levels for the pseudo efficacy responses</dd>


<dt>nu</dt>
<dd>the precision (inverse of the variance) of the efficacy responses</dd>


<dt>data</dt>
<dd>the input data of <code>DataDual</code> class to update model estimates</dd>


<dt>c</dt>
<dd>the constant value added to the dose level when the dose level value is less than or
equal to 1 and a special form of the linear log-log has to applied (Yeung et al. (2015).).</dd>

</dl>

Effloglog: Initialization function for the "Effloglog" class

Description

Usage

Value

Arguments