crmPack (version 1.0.6)

IncrementMin-class: Max increment based on minimum of multiple increment rules

Description

This class can be used to combine multiple increment rules with the MIN operation.

Slots

IncrementsList

list of increment rules

Details

IncrementsList contains all increment rules, which are again objects of class Increments. The minimum of these individual increments is taken to give the final maximum increment.

Examples

# As example, here we are combining 2 different increment rules. 

# The first rule is the following: 
#      maximum doubling the dose if no DLTs were observed at the current dose
#      or maximum increasing the dose by 1.33 if 1 or 2 DLTs were observed at the current dose
#      or maximum increasing the dose by 1.22 if 3 or more DLTs were observed

# The second rule is the following: 
#   maximum doubling the dose if the current dose is <20
#   OR only maximum increasing the dose by 1.33 if the current dose is >=20


myIncrements1 <- IncrementsRelativeDLT(DLTintervals = c(0, 1, 3),
                                      increments = c(1, 0.33, 0.2))

myIncrements2 <- IncrementsRelative(intervals=c(0, 20),
                                    increments=c(1, 0.33))

# Now we combine the 2 rules
combIncrement <- IncrementMin(IncrementsList=
                                list(myIncrements1,myIncrements2))