NextBestNCRM-class

.NextBestNCRM

Note that to avoid numerical problems, the dose selection algorithm has been
implemented as follows: First admissible doses are found, which are those
with probability to fall in <code>overdose</code> category being below
<code>maxOverdoseProb</code>. Next, within the admissible doses, the maximum
probability to fall in the <code>target</code> category is calculated. If that is
above 5% (i.e., it is not just numerical error), then the corresponding
dose is the next recommended dose. Otherwise, the highest admissible dose is
the next recommended dose.

classes

Implements a wide range of model-based dose
escalation designs, ranging from classical and modern continual
reassessment methods (CRMs) based on dose-limiting toxicity endpoints to
dual-endpoint designs taking into account a biomarker/efficacy outcome. The
focus is on Bayesian inference, making it very easy to setup a new design
with its own JAGS code. However, it is also possible to implement 3+3
designs for comparison or models with non-Bayesian estimation. The whole
package is written in a modular form in the S4 class system, making it very
flexible for adaptation to new models, escalation or stopping rules.

Daniel Sabanes Bove

crmPack

Object-Oriented Implementation of CRM Designs

Wai Yin Yeung

Giuseppe Palermo

Thomas Jaki

NextBestNCRM-class function

<dl>
<dt><code>target</code></dt>
<dd>the target toxicity interval (limits included)</dd></dl>
<dt><code>overdose</code></dt>
<dd>the overdose toxicity interval (lower limit excluded, upper
limit included)</dd>
<dt><code>maxOverdoseProb</code></dt>
<dd>maximum overdose probability that is allowed</dd>

Slots

The class with the input for finding the next dose in target interval — NextBestNCRM-class

<dl>
<dt><code>target</code></dt>
<dd>the target toxicity interval (limits included)</dd>


<dt><code>overdose</code></dt>
<dd>the overdose toxicity interval (lower limit excluded, upper
limit included)</dd>


<dt><code>maxOverdoseProb</code></dt>
<dd>maximum overdose probability that is allowed</dd>


</dl>

NextBestNCRM-class: The class with the input for finding the next dose in target interval

Description

Arguments

Slots

Examples