PseudoDualFlexiSimulations-class

.PseudoDualFlexiSimulations

This is a class which captures the trial simulations design using both the
DLE and efficacy responses. The design of model from <code>ModelTox</code>
class and the efficacy model from <code>EffFlexi</code> class 
 It contains all slots from 
<code>GeneralSimulations</code>, <code>PseudoSimulations</code> 
and <code>PseudoDualSimulations</code> object.
In comparison to the parent class <code>PseudoDualSimulations</code>, 
it contains additional slots to 
capture the sigma2betaW estimates.

class

Implements a wide range of model-based dose
escalation designs, ranging from classical and modern continual
reassessment methods (CRMs) based on dose-limiting toxicity endpoints to
dual-endpoint designs taking into account a biomarker/efficacy outcome. The
focus is on Bayesian inference, making it very easy to setup a new design
with its own JAGS code. However, it is also possible to implement 3+3
designs for comparison or models with non-Bayesian estimation. The whole
package is written in a modular form in the S4 class system, making it very
flexible for adaptation to new models, escalation or stopping rules.

Daniel Sabanes Bove

crmPack

Object-Oriented Implementation of CRM Designs

Wai Yin Yeung

Giuseppe Palermo

Thomas Jaki

PseudoDualFlexiSimulations-class function

<dl>
<dt><code>sigma2betaWest</code></dt>
<dd>the vector of the final posterior mean sigma2betaW estimates</dd></dl>

Slots

This is a class which captures the trial simulations design using both the
DLE and efficacy responses. The design of model from ModelTox
class and the efficacy model from EffFlexi class 
 It contains all slots from 
GeneralSimulations, PseudoSimulations 
and PseudoDualSimulations object.
In comparison to the parent class PseudoDualSimulations, 
it contains additional slots to 
capture the sigma2betaW estimates. — PseudoDualFlexiSimulations-class

<dl>
<dt><code>sigma2betaWest</code></dt>
<dd>the vector of the final posterior mean sigma2betaW estimates</dd>


</dl>

This is a class which captures the trial simulations design using both the
DLE and efficacy responses. The design of model from <code>ModelTox</code>
class and the efficacy model from <code>EffFlexi</code> class 
 It contains all slots from 
<code>GeneralSimulations</code>, <code>PseudoSimulations</code> 
and <code>PseudoDualSimulations</code> object.
In comparison to the parent class <code>PseudoDualSimulations</code>, 
it contains additional slots to 
capture the sigma2betaW estimates.

Description

Arguments

Slots