## for example this can be used in the following way:
## we would like to stop if:
## - next proposed dose is highest dose
## - there are already at least 3 patients on that dose
## - we are sure that this dose is safe, e.g. the
## probability to be in the interval (0%, 20%) of DLT
## rate is above 50%.
## This would be implemented as the following combination:
stopHigh <-
StoppingHighestDose() &
StoppingPatientsNearDose(nPatients=3, percentage=0) &
StoppingTargetProb(target=c(0, 0.2),
prob=0.5)
## of course this rule would then need to be combined
## with the other standard rules for when to stop
## when the MTD is found based on being near
## e.g. a 30% DLT probability or having reached maximal sample
## size, in the manner of:
## stopRule <- stopHigh | stopLow | stopSamplesize
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