ThreePlusThreeDesign

Creates a new 3+3 design object from a dose grid

programming

Implements a wide range of model-based dose
escalation designs, ranging from classical and modern continual
reassessment methods (CRMs) based on dose-limiting toxicity endpoints to
dual-endpoint designs taking into account a biomarker/efficacy outcome. The
focus is on Bayesian inference, making it very easy to setup a new design
with its own JAGS code. However, it is also possible to implement 3+3
designs for comparison or models with non-Bayesian estimation. The whole
package is written in a modular form in the S4 class system, making it very
flexible for adaptation to new models, escalation or stopping rules.

Daniel Sabanes Bove

crmPack

Object-Oriented Implementation of CRM Designs

Wai Yin Yeung

Giuseppe Palermo

Thomas Jaki

ThreePlusThreeDesign function

<dl><dt>doseGrid</dt>
<dd>the dose grid to be used</dd></dl>

Arguments

Daniel Sabanes Bove <a href="/link/sabanesd%40roche.com?package=crmPack&version=1.0.6" data-mini-rdoc="crmPack::sabanesd@roche.com">sabanesd@roche.com</a>

Author

Creates a new 3+3 design object from a dose grid — ThreePlusThreeDesign

<dl>

<dt>doseGrid</dt>
<dd>the dose grid to be used</dd>

</dl>

Daniel Sabanes Bove <a href='mailto:sabanesd@roche.com'>sabanesd@roche.com</a>

ThreePlusThreeDesign: Creates a new 3+3 design object from a dose grid

Description

Usage

Value

Arguments

Author

Examples