crmPack-package

crmPack

Object-oriented implementation of CRM designs

package

Implements a wide range of model-based dose
escalation designs, ranging from classical and modern continual
reassessment methods (CRMs) based on dose-limiting toxicity endpoints to
dual-endpoint designs taking into account a biomarker/efficacy outcome. The
focus is on Bayesian inference, making it very easy to setup a new design
with its own JAGS code. However, it is also possible to implement 3+3
designs for comparison or models with non-Bayesian estimation. The whole
package is written in a modular form in the S4 class system, making it very
flexible for adaptation to new models, escalation or stopping rules.

Daniel Sabanes Bove

Object-Oriented Implementation of CRM Designs

Wai Yin Yeung

Giuseppe Palermo

Thomas Jaki

crmPack-package function

Daniel Sabanes Bove <a href="/link/daniel.sabanes_bove%40rconis.com?package=crmPack&version=1.0.6" data-mini-rdoc="crmPack::daniel.sabanes_bove@rconis.com">daniel.sabanes_bove@rconis.com</a>,
Wai Yin Yeung <a href="/link/winnie.yeung%40roche.com?package=crmPack&version=1.0.6" data-mini-rdoc="crmPack::winnie.yeung@roche.com">winnie.yeung@roche.com</a>,
Giuseppe Palermo <a href="/link/giuseppe.palermo%40roche.com?package=crmPack&version=1.0.6" data-mini-rdoc="crmPack::giuseppe.palermo@roche.com">giuseppe.palermo@roche.com</a>,
Thomas Jaki <a href="/link/jaki.thomas%40gmail.com?package=crmPack&version=1.0.6" data-mini-rdoc="crmPack::jaki.thomas@gmail.com">jaki.thomas@gmail.com</a>

Author

Object-oriented implementation of CRM designs — crmPack-package

Daniel Sabanes Bove <a href='mailto:daniel.sabanes_bove@rconis.com'>daniel.sabanes_bove@rconis.com</a>,
Wai Yin Yeung <a href='mailto:winnie.yeung@roche.com'>winnie.yeung@roche.com</a>,
Giuseppe Palermo <a href='mailto:giuseppe.palermo@roche.com'>giuseppe.palermo@roche.com</a>,
Thomas Jaki <a href='mailto:jaki.thomas@gmail.com'>jaki.thomas@gmail.com</a>

crmPack-package: Object-oriented implementation of CRM designs

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Author

References