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disco (version 0.6)

Discordance and Concordance of Transcriptomic Responses

Description

Concordance and discordance of homologous gene regulation allows comparing reaction to stimuli in different organisms, for example human patients and animal models of a disease. The package contains functions to calculate discordance and concordance score for homologous gene pairs, identify concordantly or discordantly regulated transcriptional modules and visualize the results. It is intended for analysis of transcriptional data.

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Version

Install

install.packages('disco')

Monthly Downloads

32

Version

0.6

License

GPL (>= 2.0)

Maintainer

Teresa Domaszewska

Last Published

July 2nd, 2018

Functions in disco (0.6)

plotDisco

plots log2FC of the corresponding genes against each other
makeMatchedOrtholog

Create an object of class matchedOrtholog
orthologs

Example ortholog data set
disco.score

Calculate concordance score for differentially expressed genes in two data sets
matchedOrtholog-class

S4 class for disco
modCor

Calculate correlation between regulation of orthologous genes in a chosen gene set
percentGenes

Calculates percentage of present genes from a specified superset of expression modules
makeSummary

Common modules in specified comparisons
corOrt

Calculate ortholog gene correlation coefficients