A small example database subset from Laserson and Vigneault et al, 2014.
ExampleDbChangeo
A data.frame with the following Change-O style columns:
SEQUENCE_ID
: Sequence identifier
SEQUENCE_IMGT
: IMGT-gapped observed sequence.
GERMLINE_IMGT_D_MASK
: IMGT-gapped germline sequence with N, P and
D regions masked.
V_CALL
: V region allele assignments.
V_CALL_GENOTYPED
: TIgGER corrected V region allele assignment.
D_CALL
: D region allele assignments.
J_CALL
: J region allele assignments.
JUNCTION
: Junction region sequence.
JUNCTION_LENGTH
: Length of the junction region in nucleotides.
NP1_LENGTH
: Combined length of the N and P regions proximal
to the V region.
NP2_LENGTH
: Combined length of the N and P regions proximal
to the J region.
SAMPLE
: Sample identifier. Time in relation to vaccination.
ISOTYPE
: Isotype assignment.
DUPCOUNT
: Copy count (number of duplicates) of the sequence.
CLONE
: Change-O assignment clonal group identifier.
Laserson U and Vigneault F, et al. High-resolution antibody dynamics of vaccine-induced immune responses. Proc Natl Acad Sci USA. 2014 111:4928-33.
ExampleAirr ExampleClones