GvHD: Extract of a Graft versus Host Disease monitoring experiment
(Rizzieri et al., 2007)
Description
A flow cytometry high throughput screening was used to identify
biomarkers that would predict the development of GvHD. The GvHD dataset
is an extract of a collection of weekly peripheral blood samples
obtained from patients following allogenic blood and marrow
transplant. Samples were taken at various time points before and after
graft.
Format
The format is an object of class flowSet composed of 35
flowFrames.
Each flowFrame corresponds to one sample at one time point.
The phenodata lists:
- Patient
- The patient Id code
- Visit
- The number of visits to the hospital
- Days
- The number of days since the graft. Negative values
correpond to days before the graft.
- Grade
- Grade of the cancer
Details
This GvHD dataset represents the measurements of one biomarker
(leukocyte) for 5 patients over 7 visits (7 time points). The blood
samples were labeled with four different fluorescent probes to
identify the biomarker and the fluorescent intensity was determined
for at least ten thousand cells per sample.
References
Rizzieri DA et al. J Clin Oncol. 2007 Jan 16; [Epub ahead of print]
PMID: 17228020