lipid.scores: Genetic risk scores for serum lipid levels
Description
Risk scores parameterised using GWAS meta-analysis results published
by the Global Lipid Genetics Consortium (Teslovich et al. Nature
2010). There are scores for four different lipid level phenotypes
(High Density Lipoprotein HDL; Low Density Lipoprotein LDL; Total
Cholesterol TC; Triglycerides TG), all parameterised using genome wide
significant SNPs reported in Supplementary Table 1 of Teslovich et
al. (2010).
Format
A data frame suitable for use with other functions in this package. These scores are called HDL2010, LDL2010, TC2010 and TG2010, and have
coefficients in mg/dl per coded allele. Additional scores based on larger numbers of SNPs are available separately...
LDL.prune.0.01 and there is an additional column in the data frame,
p-value, that should be used to threshold on. The coefficients are
back-calculates from Z scores and HapMap allele frequency data.