magic.scores: Genetic risk scores for glucose/insulin traits.
Description
Risk scores parameterised using GWAS meta-analysis results published
by the MAGIC consortium (Dupuis et al. Nature Genetics 2010) for
glucose and insulin traits.
Usage
data(magic.scores)
Arguments
Format
A data frame suitable for use with other functions in this package,
see gtx.params. The scores are called FG2010 and FI2010, for fasting plasma glucose
(FG, mmol/l) and fasting insulin (FI, pmol/l), and using the 16 and 2
genome wide significant loci from Table 1 of Dupuis et al. (2010)
respectively. Effect size coefficients are taken from Table 2 of
Dupuis et al. (2010) and hence use SNPs different from those reported
in Table 1 at the SLC30A8 and TCF7L2 loci. In addition, for all SNPs in both risk scores, there are effect size
estimates (beta) and standard errors (se) for FG, HOMA-B index of beta
cell function, FI, HOMA-IR index of insulin resistance, glycated
hemoglobin (HbA1c, percent), glucose 2 hours after oral glucose
tolerance test (2hG, mmol/l), insulin 2 hours after oral glucose
tolerance test (2hI, pmol/l), type 2 diabetes risk (T2D, ln odds,
converted from odds ratio), body mass index (BMI, kg/m2), diastolic
blood pressure (DBP, mmHg), systolic blood pressure (SBP, mmHg),
hypertension risk (HTN, ln odds), and serum lipid concentrations (HDL,
LDL, TC, TG), all taken from Table 2 and Table 3 of Dupuis et
al. (2010).