hcc (version 0.54)

dicentric: Radiation dose effects on chromosomal abnormality

Description

An experiment was conducted to determine the effect of gamma radiation on the numbers of chromosomal abnormalities observed

Usage

data(dicentric)

Format

A data frame with 27 observations on the following 4 variables.

cells

Number of cells in hundreds

ca

Number of chromosomal abnormalities

doseamt

amount of dose in Grays

doserate

rate of dose in Grays/hour

Source

Purott R. and Reeder E. (1976) The effect of changes in dose rate on the yield of chromosome aberrations in human lymphocytes exposed to gamma radiation. Mutation Research. 35, 437-444.

References

Frome E. and DuFrain R. (1986) Maximum Likelihood Estimation for Cytogenic Dose-Response Curves. Biometrics. 42, 73-84 and Extending the linear model with R. Chapman & Hall/CRC Taylor & Francis Group, 2006.

Examples

data(dicentric)
dicentric$dosef <- factor(dicentric$doseamt)
rmod <- glm(ca ~ offset(log(cells))+log(doserate)*dosef, family=poisson,dicentric)
x <- dicentric[,4]
res <- resid(rmod)
hctest(x, res)