heplots (version 1.6.2)

Diabetes: Diabetes Dataset

Description

Reaven and Miller (1979) examined the relationship among blood chemistry measures of glucose tolerance and insulin in 145 nonobese adults. They used the PRIM9 system at the Stanford Linear Accelerator Center to visualize the data in 3D, and discovered a peculiar pattern that looked like a large blob with two wings in different directions.

Format

A data frame with 145 observations on the following 6 variables.

relwt

relative weight, expressed as the ratio of actual weight to expected weight, given the person's height, a numeric vector

glufast

fasting plasma glucose level, a numeric vector

glutest

test plasma glucose level, a measure of glucose intolerance, a numeric vector

instest

plasma insulin during test, a measure of insulin response to oral glucose, a numeric vector

sspg

steady state plasma glucose, a measure of insulin resistance, a numeric vector

group

diagnostic group, a factor with levels Normal Chemical_Diabetic Overt_Diabetic

Details

After further analysis, the subjects were classified as subclinical (chemical) diabetics, overt diabetics and normals. This study was influential in defining the stages of development of Type 2 diabetes. Overt diabetes is the most advanced stage, characterized by elevated fasting blood glucose concentration and classical symptoms. Preceding overt diabetes is the latent or chemical diabetic stage, with no symptoms of diabetes but demonstrable abnormality of oral or intravenous glucose tolerance.

glutest was defined as the "area under the plasma glucose curve for the three hour oral glucose tolerance test." Reaven & Miller refer to this variable as "Glucose area".

instest was defined as the "area under the plasma insulin curve", and is referred to in the paper as "Insulin area".

This study was influential in defining the stages of development of Type 2 diabetes. Overt diabetes is the most advanced stage, characterized by elevated fasting blood glucose concentration and classical symptoms. Preceding overt diabetes is the latent or chemical diabetic stage, with no symptoms of diabetes but demonstrable abnormality of oral or intravenous glucose tolerance.

References

Reaven, G. M. and Miller, R. G. (1979). An attempt to define the nature of chemical diabetes using a multidimensional analysis. Diabetologia, 16, 17-24.

Examples

data(Diabetes)
col <- c("blue", "red", "darkgreen")[Diabetes$group]
pch <- c(16,15,17)[Diabetes$group]

# a perplexing plot, similar to Fig 2, but with a loess smooth 
plot(instest ~ glutest, data=Diabetes, pch=16,
	cex.lab=1.25,
	xlab="Glucose area (glutest)",
	ylab="Insulin area (instest)")
lines( loess.smooth(Diabetes$glutest, Diabetes$instest), col="blue", lwd=2) 

# scatterplot matrix, colored by group
plot(Diabetes[,1:5], col=col, pch=pch)

# covariance ellipses
covEllipses(Diabetes[,2:5], Diabetes$group, fill=TRUE, pooled=FALSE, 
	col=col)

covEllipses(Diabetes[,2:5], Diabetes$group, fill=TRUE, pooled=FALSE, 
	col=col, variables=1:4)

# Box's M test
diab.boxm <- boxM(Diabetes[,2:5], Diabetes$group)
diab.boxm
plot(diab.boxm)

# heplots
diab.mlm <- lm(cbind(glufast, glutest, instest, sspg) ~ group, data=Diabetes)

heplot(diab.mlm)
pairs(diab.mlm, fill=TRUE, fill.alpha=0.1)