Provides methods for closed testing using Simes local tests. In particular, calculates adjusted p-values for Hommel's multiple testing method, and provides lower confidence bounds for true discovery proportions. A robust but more conservative variant of the closed testing procedure that does not require the assumption of Simes inequality is also implemented.
Jelle Goeman, Rosa Meijer, Thijmen Krebs.
Maintainer: Jelle Goeman <j.j.goeman@lumc.nl>
The starting point of the package is the hommel function. See examples there.
Hommel, G. (1988). A stagewise rejective multiple test procedure based on a modified Bonferroni test. Biometrika, 75(2), 383-386.
Meijer, R., Krebs, T., Solari, A., & Goeman, J. (2016). Simultaneous Control of All False Discovery Proportions by an Extension of Hommel's Method. arXiv preprint arXiv:1611.06739.