Provides methods for closed testing using Simes local tests. In particular, calculates adjusted p-values for Hommel's multiple testing method, and provides lower confidence bounds for true discovery proportions. A robust but more conservative variant of the closed testing procedure that does not require the assumption of Simes inequality is also implemented.
Jelle Goeman, Rosa Meijer, Thijmen Krebs.
Maintainer: Jelle Goeman <j.j.goeman@lumc.nl>
The starting point of the package is the hommel function. See examples there.
Hommel, G. (1988). A stagewise rejective multiple test procedure based on a modified Bonferroni test. Biometrika, 75(2), 383-386.
Meijer, R. J., Krebs, T. J., & Goeman, J. J. (2019). Hommel's procedure in linear time. Biometrical Journal, 61(1), 73-82.
Goeman, J. J., Meijer, R. J., Krebs, T. J., & Solari, A. (2019). Simultaneous control of all false discovery proportions in large-scale multiple hypothesis testing. Biometrika, 106(4), 841-856.