age_dist_smooth

Distributions of ages in months, computed from NHANES data smoothed using
survey::svysmooth(), for each combination of race/ethnicity and gender.

datasets

Functions and data tables for simulation and statistical analysis of chemical toxicokinetics ("TK") using data obtained from relatively high throughput, in vitro studies. Both physiologically-based ("PBTK") and empirical (e.g., one compartment) "TK" models can be parameterized for several hundred chemicals and multiple species. These models are solved efficiently, often using compiled (C-based) code. A Monte Carlo sampler is included for simulating biological variability and measurement limitations. Functions are also provided for exporting "PBTK" models to "SBML" and "JARNAC" for use with other simulation software. These functions and data provide a set of tools for in vitro-in vivo extrapolation ("IVIVE") of high throughput screening data (e.g., ToxCast) to real-world exposures via reverse dosimetry (also known as "RTK").

John Wambaugh

httk

High-Throughput Toxicokinetics

age_dist_smooth function

A data.table object with three variables:<dl class="dl-horizontal">
 <dt><code>gender</code></dt><dd>Gender: Male or Female</dd> 
 <dt><code>reth</code></dt><dd>Race/ethnicity</dd> <dt><code>smth</code></dt><dd>A list of 
 <code>svysmooth</code> objects, each encoding a weighted smoothed distribution of 
 ages.</dd></dl>

Format

Smoothed age distributions by race and gender. — age_dist_smooth

A data.table object with three variables:<dl class='dl-horizontal'>
 <dt><code>gender</code></dt><dd>Gender: Male or Female</dd> 
 <dt><code>reth</code></dt><dd>Race/ethnicity</dd> <dt><code>smth</code></dt><dd>A list of 
 <code>svysmooth</code> objects, each encoding a weighted smoothed distribution of 
 ages.</dd></dl>

age_dist_smooth: Smoothed age distributions by race and gender.

Description

Usage

Arguments

Format

References