Converts HTTK-Pop virtual population into parameters relevant to an HTTK model.
convert_httk(indiv.model.bio, model, this.chem,adjusted.Funbound.plasma=T,regression=T,
well.stirred.correction=T,restrictive.clearance=T)A data.table containing the physiological
parameters as expected by HTTK (from httkpop_bio) and
Funbound.plasma and Clint values (from
draw_fup_clint).
Which HTTK model to use. One of '1compartment', '3compartmentss', '3compartment', or 'pbtk'.
CAS number for the chemical in the HTTK data set for which parameters are to be generated.
Uses adjusted Funbound.plasma when set to TRUE along with partition coefficients calculated with this value.
Whether or not to use the regressions in calculating partition coefficients.
Uses correction in calculation of hepatic clearance for well-stirred model if TRUE for model 1compartment elimination rate. This assumes clearance relative to amount unbound in whole blood instead of plasma, but converted to use with plasma concentration.
Protein binding not taken into account (set to 1) in liver clearance if FALSE for model 1compartment elimination rate.
A data.table whose columns are the parameters of the HTTK model
specified in model.
Ring, Caroline L., et al. "Identifying populations sensitive to environmental chemicals by simulating toxicokinetic variability." Environment International 106 (2017): 105-118.