draw_fup_clint

this.chem

nsamp

The coefficient of variance to assume. Default 0.3.

sigma.factor

Logical. Whether to include poor metabolizers in the Clint 
distribution or not.

poormetab

Logical. Whether to draw <code>Funbound.plasma</code> from a 
censored distribution or not.

fup.censor

Logical, default TRUE. Whether to treat <code>Clint</code> as 
fixed at its measured value (FALSE), or as a random variable (TRUE).

Clint.vary

The average limit of detection for <code>Funbound.plasma</code>, below 
which distribution will be censored if fup.censor is TRUE. Default 0.01.

Uses adjusted Funbound.plasma value if TRUE.

adjusted.Funbound.plasma

Given a CAS in the HTTK data set, a virtual population from HTTK-Pop, some 
user specifications on the assumed distributions of Funbound.plasma and Clint,
draw "individual" values of Funbound.plasma and Clint from those 
distributions.

Functions and data tables for simulation and statistical analysis of chemical toxicokinetics ("TK") using data obtained from relatively high throughput, in vitro studies. Both physiologically-based ("PBTK") and empirical (e.g., one compartment) "TK" models can be parameterized for several hundred chemicals and multiple species. These models are solved efficiently, often using compiled (C-based) code. A Monte Carlo sampler is included for simulating biological variability and measurement limitations. Functions are also provided for exporting "PBTK" models to "SBML" and "JARNAC" for use with other simulation software. These functions and data provide a set of tools for in vitro-in vivo extrapolation ("IVIVE") of high throughput screening data (e.g., ToxCast) to real-world exposures via reverse dosimetry (also known as "RTK").

draw_fup_clint: Draw Funbound.plasma and Clint from censored or non-censored distributions.

Description

Usage

Arguments

Value