mcnally_dt

Reference tissue masses, flows, and marginal distributions from McNally et
al. 2014.

datasets

Functions and data tables for simulation and statistical analysis of chemical toxicokinetics ("TK") using data obtained from relatively high throughput, in vitro studies. Both physiologically-based ("PBTK") and empirical (e.g., one compartment) "TK" models can be parameterized for several hundred chemicals and multiple species. These models are solved efficiently, often using compiled (C-based) code. A Monte Carlo sampler is included for simulating biological variability and measurement limitations. Functions are also provided for exporting "PBTK" models to "SBML" and "JARNAC" for use with other simulation software. These functions and data provide a set of tools for in vitro-in vivo extrapolation ("IVIVE") of high throughput screening data (e.g., ToxCast) to real-world exposures via reverse dosimetry (also known as "RTK").

John Wambaugh

httk

High-Throughput Toxicokinetics

mcnally_dt function

A data.table with variables:<dl class="dl-horizontal">
 <dt><code>gender</code></dt><dd>Gender: Male or Female</dd> 
 <dt><code>mass_ref</code></dt><dd>Reference mass in kg, from Reference Man</dd> 
 <dt><code>mass_cv</code></dt><dd>Coefficient of variation for mass</dd> 
 <dt><code>mass_dist</code></dt><dd>Distribution for mass: Normal or Log-normal</dd> 
 <dt><code>flow_ref</code></dt><dd>Reference flow in L/h, from Reference Man</dd> 
 <dt><code>flow_cv</code></dt><dd>Coefficient of variation for flow (all normally 
 distributed)</dd> <dt><code>height_ref</code></dt><dd>Reference heights (by gender)</dd> 
 <dt><code>CO_ref</code></dt><dd>Reference cardiac output by gender</dd> 
 <dt><code>flow_frac</code></dt><dd>Fraction of CO flowing to each tissue: 
 <code>flow_ref</code>/<code>CO_ref</code></dd></dl>

Format

Reference tissue masses and flows from tables in McNally et al. 2014. — mcnally_dt

A data.table with variables:<dl class='dl-horizontal'>
 <dt><code>gender</code></dt><dd>Gender: Male or Female</dd> 
 <dt><code>mass_ref</code></dt><dd>Reference mass in kg, from Reference Man</dd> 
 <dt><code>mass_cv</code></dt><dd>Coefficient of variation for mass</dd> 
 <dt><code>mass_dist</code></dt><dd>Distribution for mass: Normal or Log-normal</dd> 
 <dt><code>flow_ref</code></dt><dd>Reference flow in L/h, from Reference Man</dd> 
 <dt><code>flow_cv</code></dt><dd>Coefficient of variation for flow (all normally 
 distributed)</dd> <dt><code>height_ref</code></dt><dd>Reference heights (by gender)</dd> 
 <dt><code>CO_ref</code></dt><dd>Reference cardiac output by gender</dd> 
 <dt><code>flow_frac</code></dt><dd>Fraction of CO flowing to each tissue: 
 <code>flow_ref</code>/<code>CO_ref</code></dd></dl>

mcnally_dt: Reference tissue masses and flows from tables in McNally et al. 2014.

Description

Usage

Arguments

Format