nhanes_mec_svy

NHANES data on demographics, anthropometrics, and some laboratory measures, 
cleaned and combined into a single data set.

datasets

Functions and data tables for simulation and statistical analysis of chemical toxicokinetics ("TK") using data obtained from relatively high throughput, in vitro studies. Both physiologically-based ("PBTK") and empirical (e.g., one compartment) "TK" models can be parameterized for several hundred chemicals and multiple species. These models are solved efficiently, often using compiled (C-based) code. A Monte Carlo sampler is included for simulating biological variability and measurement limitations. Functions are also provided for exporting "PBTK" models to "SBML" and "JARNAC" for use with other simulation software. These functions and data provide a set of tools for in vitro-in vivo extrapolation ("IVIVE") of high throughput screening data (e.g., ToxCast) to real-world exposures via reverse dosimetry (also known as "RTK").

John Wambaugh

httk

High-Throughput Toxicokinetics

nhanes_mec_svy function

A survey.design2 object, including masked cluster and strata. 
 Variables are available as a data.table by <code>nhanes_mec_svy$variables</code>. 
 Variables are as described in NHANES Demographics and Examination 
 documentation, with the exception of:<dl class="dl-horizontal">
 <dt><code>wtmec6yr</code></dt><dd>6-year sample weights for combining 3 cycles, 
 computed by dividing 2-year sample weights by 3.</dd> 
 <dt><code>bmxhtlenavg</code></dt><dd>Average of height and recumbent length if both 
 were measured; if only one was measured, takes value of the one that was 
 measured.</dd> <dt><code>logbmxwt</code></dt><dd>Natural log of measured body weight.</dd> 
 <dt><code>logbmxhtlenavg</code></dt><dd>Natural log of <code>bmxhtlenavg</code>.</dd> 
 <dt><code>weight_class</code></dt><dd>One of Underweight, Normal, Overweight, or Obese.
 Assigned using methods in <code>get_weight_class</code>.</dd> </dl>

Format

Pre-processed NHANES data. — nhanes_mec_svy

A survey.design2 object, including masked cluster and strata. 
 Variables are available as a data.table by <code>nhanes_mec_svy$variables</code>. 
 Variables are as described in NHANES Demographics and Examination 
 documentation, with the exception of:<dl class='dl-horizontal'>
 <dt><code>wtmec6yr</code></dt><dd>6-year sample weights for combining 3 cycles, 
 computed by dividing 2-year sample weights by 3.</dd> 
 <dt><code>bmxhtlenavg</code></dt><dd>Average of height and recumbent length if both 
 were measured; if only one was measured, takes value of the one that was 
 measured.</dd> <dt><code>logbmxwt</code></dt><dd>Natural log of measured body weight.</dd> 
 <dt><code>logbmxhtlenavg</code></dt><dd>Natural log of <code>bmxhtlenavg</code>.</dd> 
 <dt><code>weight_class</code></dt><dd>One of Underweight, Normal, Overweight, or Obese.
 Assigned using methods in <code>get_weight_class</code>.</dd> </dl>

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nhanes_mec_svy: Pre-processed NHANES data.

Description

Usage

Arguments

Format