spline_heightweight

#'Smoothing splines and KDE fits to joint distribution of height and weight
residuals pre-calculated from NHANES height, weight, and age data by
race/ethnicity and gender.

datasets

Functions and data tables for simulation and statistical analysis of chemical toxicokinetics ("TK") using data obtained from relatively high throughput, in vitro studies. Both physiologically-based ("PBTK") and empirical (e.g., one compartment) "TK" models can be parameterized for several hundred chemicals and multiple species. These models are solved efficiently, often using compiled (C-based) code. A Monte Carlo sampler is included for simulating biological variability and measurement limitations. Functions are also provided for exporting "PBTK" models to "SBML" and "JARNAC" for use with other simulation software. These functions and data provide a set of tools for in vitro-in vivo extrapolation ("IVIVE") of high throughput screening data (e.g., ToxCast) to real-world exposures via reverse dosimetry (also known as "RTK").

John Wambaugh

httk

High-Throughput Toxicokinetics

spline_heightweight function

A data.table with 6 variables:<dl class="dl-horizontal">
<dt><code>g</code></dt><dd>Gender: Male
 or Female</dd> <dt><code>r</code></dt><dd>Race/ethnicity: Mexican American, Other Hispanic,
 Non-Hispanic White, Non-Hispanic Black, Other</dd> <dt><code>height_spline</code></dt><dd>A
 list of smooth.spline objects, each giving a smoothed relationship between 
 log height in cm and age in months</dd> <dt><code>weight_spline</code></dt><dd>A list of 
 smooth.spline objects, each giving a smoothed relationship between log body 
 weight in kg and age in months</dd> <dt><code>hw_kde</code></dt><dd>A list of kde objects;
 each is a 2-D KDE of the distribution of log height and log body weight
 residuals about the smoothing splines.</dd> </dl>

Format

Smoothing splines for log height vs. age and log body weight vs. age, along 
with 2-D KDE residuals, by race and gender. — spline_heightweight

A data.table with 6 variables:<dl class='dl-horizontal'>
<dt><code>g</code></dt><dd>Gender: Male
 or Female</dd> <dt><code>r</code></dt><dd>Race/ethnicity: Mexican American, Other Hispanic,
 Non-Hispanic White, Non-Hispanic Black, Other</dd> <dt><code>height_spline</code></dt><dd>A
 list of smooth.spline objects, each giving a smoothed relationship between 
 log height in cm and age in months</dd> <dt><code>weight_spline</code></dt><dd>A list of 
 smooth.spline objects, each giving a smoothed relationship between log body 
 weight in kg and age in months</dd> <dt><code>hw_kde</code></dt><dd>A list of kde objects;
 each is a 2-D KDE of the distribution of log height and log body weight
 residuals about the smoothing splines.</dd> </dl>

spline_heightweight: Smoothing splines for log height vs. age and log body weight vs. age, along with 2-D KDE residuals, by race and gender.

Description

Usage

Arguments

Format

References