tissue.data

<p>This data set contains values from Schmitt (2008) and Ruark et al. (2014) describing the composition
of specific tissues and from Birnbaum et al. (1994) describing
volumes of and blood flows to those tissues, allowing parameterization of 
toxicokinetic models for human, mouse, rat, dog, or rabbit. Tissue volumes were calculated by converting the fractional mass of each tissue with its density (both from ICRP), lumping the remaining tissues into the rest-of-body, excluding the mass of the gastrointestinal contents</p>

datasets

Functions and data tables for simulation and statistical analysis of chemical toxicokinetics ("TK") using data obtained from relatively high throughput, in vitro studies. Both physiologically-based ("PBTK") and empirical (e.g., one compartment) "TK" models can be parameterized for several hundred chemicals and multiple species. These models are solved efficiently, often using compiled (C-based) code. A Monte Carlo sampler is included for simulating biological variability and measurement limitations. Functions are also provided for exporting "PBTK" models to "SBML" and "JARNAC" for use with other simulation software. These functions and data provide a set of tools for in vitro-in vivo extrapolation ("IVIVE") of high throughput screening data (e.g., ToxCast) to real-world exposures via reverse dosimetry (also known as "RTK").

John Wambaugh

httk

High-Throughput Toxicokinetics

tissue.data function

<p>A data.frame containing 13 rows and 20 columns.</p>

tissue.data: Tissue composition and species-specific physiology parameters

Description

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References