tissue_masses_flows

<p>A data.table generated by
<code>gen_age_height_weight()</code>, containing variables <code>gender</code>,
<code>reth</code>, <code>age_months</code>, <code>age_years</code>, <code>weight</code>, and
<code>height</code>.</p>

tmf_dt

<p>Given a data.table describing a virtual population by the NHANES quantities, 
generates HTTK physiological parameters for each individual.</p>

Functions and data tables for simulation and statistical analysis of chemical toxicokinetics ("TK") using data obtained from relatively high throughput, in vitro studies. Both physiologically-based ("PBTK") and empirical (e.g., one compartment) "TK" models can be parameterized for several hundred chemicals and multiple species. These models are solved efficiently, often using compiled (C-based) code. A Monte Carlo sampler is included for simulating biological variability and measurement limitations. Functions are also provided for exporting "PBTK" models to "SBML" and "JARNAC" for use with other simulation software. These functions and data provide a set of tools for in vitro-in vivo extrapolation ("IVIVE") of high throughput screening data (e.g., ToxCast) to real-world exposures via reverse dosimetry (also known as "RTK").

John Wambaugh

httk

High-Throughput Toxicokinetics

tissue_masses_flows function

Given a data.table describing a virtual population by the NHANES quantities, 
generates HTTK physiological parameters for each individual. — tissue_masses_flows

tissue_masses_flows: Given a data.table describing a virtual population by the NHANES quantities, generates HTTK physiological parameters for each individual.

Description

Usage

Arguments

Value

References