httk (version 1.9.2)

available_rblood2plasma: Find the best available ratio of the blood to plasma concentration constant.

Description

This function finds the best available constant ratio of the blood concentration to the plasma concentration, using get_rblood2plasma and calc_rblood2plasma.

Usage

available_rblood2plasma(chem.cas=NULL, chem.name=NULL,species="Human",
                        adjusted.Funbound.plasma=T)

Arguments

chem.name

Either the chemical name or the CAS number must be specified.

chem.cas

Either the CAS number or the chemical name must be specified.

species

Species desired (either "Rat", "Rabbit", "Dog", "Mouse", or default "Human").

adjusted.Funbound.plasma

Whether or not to use Funbound.plasma adjustment if calculating Rblood2plasma.

Details

If available, in vivo data (from chem.physical_and_invitro.data) for the given species is returned, substituting the human in vivo value when missing for other species. In the absence of in vivo data, the value is calculated with calc_rblood2plasma for the given species. If Funbound.plasma is unvailable for the given species, the human Funbound.plasma is substituted. If none of these are available, the mean human Rblood2plasma from chem.physical_and_invitro.data is returned.

Examples

# NOT RUN {
available_rblood2plasma(chem.name="Bisphenol A",adjusted.Funbound.plasma=FALSE)
available_rblood2plasma(chem.name="Bisphenol A",species="Rat")
# }