httk (version 1.9.2)

calc_elimination_rate: Calculate the elimination rate for a one compartment model.

Description

This function calculates an elimination rate from the three compartment steady state model where elimination is entirely due to metablism by the liver and glomerular filtration in the kidneys.

Usage

calc_elimination_rate(chem.cas=NULL,chem.name=NULL,parameters=NULL,
                      species="Human",suppress.messages=F,default.to.human=F,
                      restrictive.clearance=T,adjusted.Funbound.plasma=T,
                      regression=T,well.stirred.correction=T, 
                      clint.pvalue.threshold = 0.05)

Arguments

chem.name

Either the chemical name or the cas number must be specified.

chem.cas

Either the cas number or the chemical name must be specified.

parameters

Chemical parameters from parameterize_steadystate or 1compartment function, overrides chem.name and chem.cas.

species

Species desired (either "Rat", "Rabbit", "Dog", "Mouse", or default "Human").

suppress.messages

Whether or not the output message is suppressed.

default.to.human

Substitutes missing animal values with human values if true.

adjusted.Funbound.plasma

Uses adjusted Funbound.plasma when set to TRUE along with partition coefficients calculated with this value.

regression

Whether or not to use the regressions in calculating partition coefficients.

restrictive.clearance

In calculating elimination rate, protein binding is not taken into account (set to 1) in liver clearance if FALSE.

well.stirred.correction

Uses correction in calculation of hepatic clearance for well-stirred model if TRUE. This assumes clearance relative to amount unbound in whole blood instead of plasma, but converted to use with plasma concentration.

clint.pvalue.threshold

Hepatic clearance for chemicals where the in vitro clearance assay result has a p-values greater than the threshold are set to zero.

Value

Elimination rate

Units of 1/h.

Details

Elimination rate calculated by dividing the total clearance (using the default well-stirred hepatic model) by the volume of distribution.

Examples

# NOT RUN {
calc_elimination_rate(chem.name="Bisphenol A")
calc_elimination_rate(chem.name="Bisphenol A",species="Rat")
calc_elimination_rate(chem.cas="80-05-7")
# }