httk (version 1.9.2)

calc_rblood2plasma: Calculate the constant ratio of the blood concentration to the plasma concentration.

Description

This function calculates the constant ratio of the blood concentration to the plasma concentration.

Usage

calc_rblood2plasma(chem.cas=NULL, chem.name=NULL, params = NULL, 
                   hematocrit = NULL, default.to.human=F, 
                   species="Human",adjusted.Funbound.plasma=T)

Arguments

chem.name

Either the chemical name or the CAS number must be specified.

chem.cas

Either the CAS number or the chemical name must be specified.

params

Parameters from parameterize_schmitt.

hematocrit

Overwrites default hematocrit value in calculating Rblood2plasma.

default.to.human

Substitutes missing animal values with human values if true.

species

Species desired (either "Rat", "Rabbit", "Dog", "Mouse", or default "Human").

adjusted.Funbound.plasma

Whether or not to use Funbound.plasma adjustment.

Details

The red blood cell (RBC) parition coefficient as predicted by the Schmitt (2008) method is used in the calculation. The value is calculated with the equation: 1 - hematocrit + hematocrit * Krbc2pu * Funbound.plasma, summing the red blood cell to plasma and plasma:plasma (equal to 1) partition coefficients multiplied by their respective fractional volumes.

References

Schmitt W. "General approach for the calculation of tissue to plasma partition coefficients." Toxicology In Vitro, 22, 457-467 (2008).

Examples

# NOT RUN {
calc_rblood2plasma(chem.name="Bisphenol A")
calc_rblood2plasma(chem.name="Bisphenol A",species="Rat")
# }