httkpop

httkpop-package

The httkpop package generates virtual population physiologies for use in 
population TK.

httk-pop

Functions and data tables for simulation and statistical analysis
of chemical toxicokinetics ("TK") as in Pearce et al. (2017)
<doi:10.18637/jss.v079.i04>. Chemical-specific in vitro
data have been obtained from relatively high throughput
experiments. Both physiologically-based ("PBTK") and empirical
(e.g., one compartment) "TK" models can be parameterized for
several hundred chemicals and multiple species. These models are
solved efficiently, often using compiled (C-based) code. A Monte
Carlo sampler is included for simulating biological variability
(Ring et al., 2017 <doi:10.1016/j.envint.2017.06.004>)
and measurement limitations. Calibrated methods are included for
predicting tissue:plasma partition coefficients and volume of
distribution
(Pearce et al., 2017 <doi:10.1007/s10928-017-9548-7>).
These functions and data provide a set of tools for
in vitro-in vivo extrapolation ("IVIVE") of high throughput
screening data (e.g., Tox21, ToxCast) to real-world exposures via
reverse dosimetry (also known as "RTK")
(Wetmore et al., 2015 <doi:10.1093/toxsci/kfv171>).

John Wambaugh

httk

High-Throughput Toxicokinetics

Robert Pearce

Caroline Ring

Greg Honda

Jimena Davis

Nisha Sipes

Barbara Wetmore

Woodrow Setzer

httkpop function

If you just want to generate
 a table of (chemical-independent) population physiology parameters, use 
 <code><a rd-options="" href="/link/httkpop_generate?package=httk&version=1.9.2" data-mini-rdoc="httk::httkpop_generate">httkpop_generate</a></code>.

Main function to generate a population

To generate a population and then run an 
 HTTK model for that population, the workflow is as follows:<ol>
<li>Generate a population using <code><a rd-options="" href="/link/httkpop_generate?package=httk&version=1.9.2" data-mini-rdoc="httk::httkpop_generate">httkpop_generate</a></code>.</li>
<li>For
 a given HTTK chemical and general model, convert the population data to 
 corresponding sets of HTTK model parameters using 
 <code><a rd-options="" href="/link/get_httk_params?package=httk&version=1.9.2" data-mini-rdoc="httk::get_httk_params">get_httk_params</a></code>.</li>
</ol>

Using HTTK-Pop with HTTK

httkpop: Virtual population generator for HTTK. — httkpop

httkpop: Virtual population generator for HTTK.

httkpop: httkpop: Virtual population generator for HTTK.

Description

Arguments

Main function to generate a population

Using HTTK-Pop with HTTK

References