nhanes_mec_svy

NHANES data on demographics, anthropometrics, and some laboratory measures, 
cleaned and combined into a single data set.

data

httk-pop

Functions and data tables for simulation and statistical analysis
of chemical toxicokinetics ("TK") as in Pearce et al. (2017)
<doi:10.18637/jss.v079.i04>. Chemical-specific in vitro
data have been obtained from relatively high throughput
experiments. Both physiologically-based ("PBTK") and empirical
(e.g., one compartment) "TK" models can be parameterized for
several hundred chemicals and multiple species. These models are
solved efficiently, often using compiled (C-based) code. A Monte
Carlo sampler is included for simulating biological variability
(Ring et al., 2017 <doi:10.1016/j.envint.2017.06.004>)
and measurement limitations. Calibrated methods are included for
predicting tissue:plasma partition coefficients and volume of
distribution
(Pearce et al., 2017 <doi:10.1007/s10928-017-9548-7>).
These functions and data provide a set of tools for
in vitro-in vivo extrapolation ("IVIVE") of high throughput
screening data (e.g., Tox21, ToxCast) to real-world exposures via
reverse dosimetry (also known as "RTK")
(Wetmore et al., 2015 <doi:10.1093/toxsci/kfv171>).

John Wambaugh

httk

High-Throughput Toxicokinetics

Robert Pearce

Caroline Ring

Greg Honda

Jimena Davis

Nisha Sipes

Barbara Wetmore

Woodrow Setzer

nhanes_mec_svy function

A survey.design2 object, including masked cluster and strata. 
 Variables are available as a data.table by <code>nhanes_mec_svy$variables</code>. 
 Variables are as described in NHANES Demographics and Examination 
 documentation, with the exception of:<dl class="dl-horizontal">
 <dt><code>wtmec6yr</code></dt><dd>6-year sample weights for combining 3 cycles, 
 computed by dividing 2-year sample weights by 3.</dd> 
 <dt><code>bmxhtlenavg</code></dt><dd>Average of height and recumbent length if both 
 were measured; if only one was measured, takes value of the one that was 
 measured.</dd> <dt><code>logbmxwt</code></dt><dd>Natural log of measured body weight.</dd> 
 <dt><code>logbmxhtlenavg</code></dt><dd>Natural log of <code>bmxhtlenavg</code>.</dd> 
 <dt><code>weight_class</code></dt><dd>One of Underweight, Normal, Overweight, or Obese.
 Assigned using methods in <code>get_weight_class</code>.</dd> </dl>

Format

Pre-processed NHANES data. — nhanes_mec_svy

A survey.design2 object, including masked cluster and strata. 
 Variables are available as a data.table by <code>nhanes_mec_svy$variables</code>. 
 Variables are as described in NHANES Demographics and Examination 
 documentation, with the exception of:<dl class='dl-horizontal'>
 <dt><code>wtmec6yr</code></dt><dd>6-year sample weights for combining 3 cycles, 
 computed by dividing 2-year sample weights by 3.</dd> 
 <dt><code>bmxhtlenavg</code></dt><dd>Average of height and recumbent length if both 
 were measured; if only one was measured, takes value of the one that was 
 measured.</dd> <dt><code>logbmxwt</code></dt><dd>Natural log of measured body weight.</dd> 
 <dt><code>logbmxhtlenavg</code></dt><dd>Natural log of <code>bmxhtlenavg</code>.</dd> 
 <dt><code>weight_class</code></dt><dd>One of Underweight, Normal, Overweight, or Obese.
 Assigned using methods in <code>get_weight_class</code>.</dd> </dl>

Pre-processed NHANES data.

nhanes_mec_svy: Pre-processed NHANES data.

Description

Usage

Arguments

Format

References