available_rblood2plasma

This function finds the best available constant ratio of the blood
concentration to the plasma concentration, using get_rblood2plasma and
calc_rblood2plasma.

Parameter

Generic models and chemical-specific data for simulation and
statistical analysis of chemical toxicokinetics ("TK") as
described by Pearce et al. (2017) <doi:10.18637/jss.v079.i04>.
Chemical-specific in vitro data have been obtained from relatively
high-throughput experiments. Both physiologically-based ("PBTK")
and empirical (for example, one compartment) "TK" models can be
parameterized with the data provided for thousands of chemicals,
multiple exposure routes, and various species. The models consist
of systems of ordinary differential equations which are solved
using compiled (C-based) code for speed. A Monte Carlo sampler is
included, which allows for simulating human biological variability
(Ring et al., 2017 <doi:10.1016/j.envint.2017.06.004>)
and propagating parameter uncertainty. Calibrated methods are
included for predicting tissue:plasma partition coefficients and
volume of distribution
(Pearce et al., 2017 <doi:10.1007/s10928-017-9548-7>).
These functions and data provide a set of tools for
in vitro-in vivo extrapolation ("IVIVE") of high-throughput
screening data (for example, Tox21, ToxCast) to real-world
exposures via reverse dosimetry (also known as "RTK")
(Wetmore et al., 2015 <doi:10.1093/toxsci/kfv171>).

John Wambaugh

httk

High-Throughput Toxicokinetics

Sarah Davidson

Robert Pearce

Caroline Ring

Greg Honda

Mark Sfeir

Matt Linakis

Dustin Kapraun

Miyuki Breen

Shannon Bell

Xiaoqing Chang

Todor Antonijevic

Jimena Davis

James Sluka

Nisha Sipes

Barbara Wetmore

Woodrow Setzer

available_rblood2plasma function

<dl><dt>chem.cas</dt>
<dd>Either the CAS number or the chemical name must be
specified.</dd>
<dt>chem.name</dt>
<dd>Either the chemical name or the CAS number must be
specified.</dd>
<dt>dtxsid</dt>
<dd>EPA's 'DSSTox Structure ID (https://comptox.epa.gov/dashboard)
the chemical must be identified by either CAS, name, or DTXSIDs</dd>
<dt>species</dt>
<dd>Species desired (either "Rat", "Rabbit", "Dog", "Mouse", or
default "Human").</dd>
<dt>adjusted.Funbound.plasma</dt>
<dd>Whether or not to use Funbound.plasma
adjustment if calculating Rblood2plasma.</dd>
<dt>suppress.messages</dt>
<dd>Whether or not to display relevant warning messages
to user.</dd></dl>

Arguments

Author

Find the best available ratio of the blood to plasma concentration constant. — available_rblood2plasma

<dl>

<dt>chem.cas</dt>
<dd>Either the CAS number or the chemical name must be
specified.</dd>


<dt>chem.name</dt>
<dd>Either the chemical name or the CAS number must be
specified.</dd>


<dt>dtxsid</dt>
<dd>EPA's 'DSSTox Structure ID (https://comptox.epa.gov/dashboard)
the chemical must be identified by either CAS, name, or DTXSIDs</dd>


<dt>species</dt>
<dd>Species desired (either "Rat", "Rabbit", "Dog", "Mouse", or
default "Human").</dd>


<dt>adjusted.Funbound.plasma</dt>
<dd>Whether or not to use Funbound.plasma
adjustment if calculating Rblood2plasma.</dd>


<dt>suppress.messages</dt>
<dd>Whether or not to display relevant warning messages
to user.</dd>

</dl>

Find the best available ratio of the blood to plasma concentration constant.

available_rblood2plasma: Find the best available ratio of the blood to plasma concentration constant.

Description

Usage

Value

Arguments

Author

Details

Examples