httkpop_mc

This is the core function for httk-pop correlated human physiological 
variability simulation as described by Ring et al. (2017) 
(tools:::Rd_expr_doi("10.1016/j.envint.2017.06.004")). This functions 
takes the data table of population biometrics (one individual per row)
generated by <code>httkpop_generate</code>, and converts it
to the corresponding table of HTTK model parameters for a specified HTTK 
model.

Monte-Carlo

httk-pop

Pre-made models that can be rapidly tailored to various chemicals
and species using chemical-specific in vitro data and physiological
information. These tools allow incorporation of chemical
toxicokinetics ("TK") and in vitro-in vivo extrapolation ("IVIVE")
into bioinformatics, as described by Pearce et al. (2017)
(<doi:10.18637/jss.v079.i04>). Chemical-specific
in vitro data characterizing toxicokinetics have been obtained
from relatively high-throughput experiments. The
chemical-independent ("generic") physiologically-based ("PBTK") and empirical
(for example, one compartment) "TK" models included here can be
parameterized with in vitro data or in silico predictions which are
provided for thousands of chemicals, multiple exposure routes,
and various species. High throughput toxicokinetics ("HTTK") is the
combination of in vitro data and generic models. We establish the
expected accuracy of HTTK for chemicals without in vivo data
through statistical evaluation of HTTK predictions for chemicals
where in vivo data do exist. The models are systems of ordinary
differential equations that are developed in MCSim and solved
using compiled (C-based) code for speed. A Monte Carlo sampler is
included for simulating human biological variability
(Ring et al., 2017 <doi:10.1016/j.envint.2017.06.004>)
and propagating parameter uncertainty
(Wambaugh et al., 2019 <doi:10.1093/toxsci/kfz205>).
Empirically calibrated methods are included for predicting
tissue:plasma partition coefficients and volume of distribution
(Pearce et al., 2017 <doi:10.1007/s10928-017-9548-7>).
These functions and data provide a set of tools for using IVIVE to
convert concentrations from high-throughput screening experiments
(for example, Tox21, ToxCast) to real-world exposures via reverse
dosimetry (also known as "RTK")
(Wetmore et al., 2015 <doi:10.1093/toxsci/kfv171>).

John Wambaugh

httk

High-Throughput Toxicokinetics

Sarah Davidson-Fritz

Robert Pearce

Caroline Ring

Greg Honda

Mark Sfeir

Matt Linakis

Dustin Kapraun

Nathan Pollesch

Miyuki Breen

Shannon Bell

Xiaoqing Chang

Todor Antonijevic

Jimena Davis

Elaina Kenyon

Katie Paul Friedman

Celia Schacht

Meredith Scherer

James Sluka

Noelle Sinski

Nisha Sipes

Barbara Wetmore

Lily Whipple

Woodrow Setzer

httkpop_mc function

<dl><dt>model</dt>
<dd>One of the HTTK models: "1compartment", "3compartmentss",
"3compartment", or "pbtk".</dd>
<dt>samples</dt>
<dd>The number of Monte Carlo samples to use (can often think of these
as separate individuals)</dd>
<dt>httkpop.dt</dt>
<dd>A data table generated by <code>httkpop_generate</code>.
This defaults to NULL, in which case <code>httkpop_generate</code> is 
called to generate this table.</dd>
<dt>...</dt>
<dd>Additional arugments passed on to <code>httkpop_generate</code>.</dd></dl>

Arguments

Author

httk-pop: Correlated human physiological parameter Monte Carlo — httkpop_mc

<dl>

<dt>model</dt>
<dd>One of the HTTK models: "1compartment", "3compartmentss",
"3compartment", or "pbtk".</dd>


<dt>samples</dt>
<dd>The number of Monte Carlo samples to use (can often think of these
as separate individuals)</dd>


<dt>httkpop.dt</dt>
<dd>A data table generated by <code>httkpop_generate</code>.
This defaults to NULL, in which case <code>httkpop_generate</code> is 
called to generate this table.</dd>


<dt>...</dt>
<dd>Additional arugments passed on to <code>httkpop_generate</code>.</dd>

</dl>

httk-pop: Correlated human physiological parameter Monte Carlo

httkpop_mc: httk-pop: Correlated human physiological parameter Monte Carlo

Description

Usage

Value

Arguments

Author

Details

References

Examples