Integrated Discovery of Oncogenic Signatures
Description
A method to integrate molecular profiles of cancer patients (gene copy number and mRNA abundance) to
identify candidate gain of function alterations. These candidate alterations can be subsequently further tested
to discover cancer driver alterations. Briefly, this method tests of genomic correlates of mRNA dysregulation and prioritise
those where DNA gains/amplifications are associated with elevated mRNA expression of the same gene. For details see,
Haider S et al. (2016) "Genomic alterations underlie a pan-cancer metabolic shift associated with tumour hypoxia", Genome Biology, .