Calculate area under the plasma concentration vs. time curve for the 1-compartment model, using an analytical equation (the integral of the 1-compartment model equation with respect to time).
auc_1comp_cl(params, time, dose, route, medium)A vector of plasma AUC values (concentration*time) corresponding to `time`.
A named numeric vector of model parameter values. See Details for requirements.
A numeric vector of times, reflecting the time point when concentration is measured after the corresponding single bolus dose. Must be same length as `dose` and `iv.dose`, or length 1.
A numeric vector of doses, reflecting single bolus doses administered at time 0. Must be same length as `time` and `iv.dose`, or length 1.
A character vector, reflecting the route of administration of each single bolus dose: `'oral'` or `'iv'`. Must be same length as `time` and `dose`, or length 1.
A character vector reflecting the medium in which each resulting concentration is to be calculated: "blood" or "plasma". Default is "plasma". Must be same length as `time` and `dose`, or length 1.
Caroline Ring, John Wambaugh
# Required parameters
`params` must include the following named items:
Fraction of compound unbound in plasma. Unitless.
Intrinsic clearance by hepatocytes. Units: 1/hr
Total blood flow through the liver. Units: L/h/kg body weight ^ (3/4)
Glomerular filtration rate, how quickly do kidneys filter. Units: L/h/kg body weight ^ (3/4)
Apparent volume of central compartment, volume/unit BW. Or see below for `Fgutabs_Vdist`
For oral administration (if any `route include:
Oral bioavailability, unitless fraction. Or see below for `Fgutabs_Vdist`
Rate of absorption from gut, 1/time.
For oral administration, in lieu of `Vdist` and `Fgutabs`, you may instead provide `Fgutabs_Vdist`, the ratio of Fgutabs to Vdist (1/volume). This is an alternate parameterization for situations where `Fgutabs` and `Vdist` are not identifiable separately (i.e., when oral TK data are available, but IV data are not). If `Fgutabs` and `Vdist` are provided, they will override any value provided for `Fgutabs_Vdist`.
If both oral and IV administration are specified (i.e., some `route and some `route `Fgutabs` or `Fgutabs_Vdist`. (If `Vdist` and `Fgutabs_Vdist` are provided, but `Fgutabs` is not provided, then `Fgutabs` will be calculated from `Vdist` and `Fgutabs_Vdist`.)
If `any(medium `Rblood2plasma`, the ratio of chemical concentration in whole blood to the chemical concentration in blood plasma.
Other built-in model functions:
auc_1comp(),
auc_2comp(),
auc_flat(),
cp_1comp(),
cp_1comp_cl(),
cp_2comp(),
cp_2comp_dt(),
cp_flat(),
get_params_1comp(),
get_params_1comp_cl(),
get_params_1comp_fup(),
get_params_2comp(),
get_params_flat(),
get_starts_1comp(),
get_starts_1comp_cl(),
get_starts_1comp_fup(),
get_starts_2comp(),
get_starts_flat(),
tkstats_2comp(),
transformed_params_2comp()
Other 1-compartment model functions:
auc_1comp(),
cp_1comp(),
cp_1comp_cl(),
get_params_1comp(),
get_params_1comp_cl(),
get_params_1comp_fup(),
get_starts_1comp(),
get_starts_1comp_cl(),
get_starts_1comp_fup()
Other model AUC functions:
auc_1comp(),
auc_2comp(),
auc_flat()