tkstats_flat

Takes in vivo toxicokinetic concentration-time data and fits
parameters of 1-compartment and 2-compartment models for each
chemical. These methods are described in detail in "Informatics for Toxicokinetics" (submitted).

John Wambaugh

invivoPKfit

Fits Toxicokinetic Models to In Vivo PK Data Sets

Caroline Ring

Gilberto Padilla Mercado

Chris Cook

tkstats_flat function

<dl><dt>pars</dt>
<dd>A named numeric vector of model parameters (e.g. from [coef.pk()]).</dd>
<dt>route</dt>
<dd>Character: The route for which to compute TK stats. Currently
only "oral" and "iv" are supported.</dd>
<dt>medium</dt>
<dd>Character: the media (tissue) for which to compute TK stats.
Currently only "blood" and "plasma" are supported.</dd>
<dt>dose</dt>
<dd>Numeric: A dose for which to calculate TK stats.</dd>
<dt>time_unit</dt>
<dd>Character: the units of time.</dd>
<dt>conc_unit</dt>
<dd>Character: The units of concentration.</dd>
<dt>vol_unit</dt>
<dd>Character: The units of dose.</dd>
<dt>...</dt>
<dd>Additional arguments not currently in use.</dd></dl>

Arguments

Author

TK stats for flat model — tkstats_flat

<dl>

<dt>pars</dt>
<dd>A named numeric vector of model parameters (e.g. from [coef.pk()]).</dd>


<dt>route</dt>
<dd>Character: The route for which to compute TK stats. Currently
only "oral" and "iv" are supported.</dd>


<dt>medium</dt>
<dd>Character: the media (tissue) for which to compute TK stats.
Currently only "blood" and "plasma" are supported.</dd>


<dt>dose</dt>
<dd>Numeric: A dose for which to calculate TK stats.</dd>


<dt>time_unit</dt>
<dd>Character: the units of time.</dd>


<dt>conc_unit</dt>
<dd>Character: The units of concentration.</dd>


<dt>vol_unit</dt>
<dd>Character: The units of dose.</dd>


<dt>...</dt>
<dd>Additional arguments not currently in use.</dd>

</dl>

TK stats for flat model

tkstats_flat: TK stats for flat model

Description

Usage

Value

Arguments

Author