This is a dataset on 407 patients suffering from chronic kidney disease who underwent a primary renal transplantation with a graft from a deceased or living donor in the University Hospital of the Catholic University of Leuven (Belgium) between 21 January 1983 and 16 August 2000. Chronic kidney (renal) disease is a progressive loss of renal function over a period of months or years through five stages. Each stage is a progression through an abnormally low and progressively worse glomerular filtration rate (GFR). The dataset records 3 repeated measures (2 continuous and 1 binary), and an event time.
data(renal)This is a list with 4 data frames:
prot: repeated measurement data for proteinuria (binary) that
measures whether the kidneys succeed in sustaining the proteins in the
blood and not discard them in the urine.
haem: repeated measurement data for blood haematocrit level
(continuous) that measures whether the kidneys produce adequate amounts of
the hormone erythropoietin that regulates the red blood cell production.
gfr: repeated measurement data for GFR (continuous) that
measures the filtration rate of the kidneys.
surv: time-to-event data for renal graft failure.
All datasets have the common data columns, which are in long format for the 3 longitudinal data data frames, and 1-per-subject for the time-to-event data frame:
idnumber for patient identification.
ageage of patient at day of surgery (years).
weightpreoperative weight of patient (kg).
sexgender of patient.
fuyearsmaximum follow up time, with transplant date as the time origin (years).
failurecensoring indicator (1=graft failure and
0=censored).
The longitudinal datasets only contain 2 further columns:
timeobserved time point, with surgery date as the time origin (years).
a recorded measurement of the biomarker taken at
time time. The 3 biomarkers (one per data frame) are:
proteinuria: recorded as binary indicator: present or
not-present. Present in the prot data.
haematocrit: recorded as percentage (%) of the ratio of the
volume of red blood cells to the total volume of blood. Present in the
haem data.
gfr: measured as ml/min/1.73\(m^2\). Present in the
gfr data.
Rizopoulos D, Ghosh, P. A Bayesian semiparametric multivariate joint model for multiple longitudinal outcomes and a time-to-event. Stat Med. 2011; 30(12): 1366-80.
pbc2, heart.valve,
epileptic.qol.